The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines.

@article{Vokes1992TheIO,
  title={The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines.},
  author={Everett E. Vokes and Michael H. Beckett and Theodore M. Karrison and Ralph R. Weichselbaum},
  journal={Oncology},
  year={1992},
  volume={49 6},
  pages={
          454-60
        }
}
We have investigated the effects of 5-fluorouracil (5-FU) and hydroxyurea (HU) with radiation on two human head and neck squamous carcinoma cell lines. SQ-20B has a D0 of 239 cGy and an S phase fraction of 37%, while SQ-38 has a D0 of 146 cGy and an S phase fraction of 31%. For SQ-20B the surviving fraction at 100 cGy was significantly reduced (p < 0.05) when cells were exposed to HU or to 5-FU or both chemotherapy agents together with radiation. No significant effect was seen for SQ-38 with… CONTINUE READING
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