The interaction of Δ9-tetrahydrocannabinol pretreatment with various sedative-hypnotic drugs

Abstract

Pretreatment with a fixed dose of δ 9-THC (20.0 mg/kg) produced a significant increase in the duration of action and number of mice exhibiting loss of the righting reflex (decrease in hypnotic dose50) after administration of several doses of nine different sedative-hypnotic drugs. Moreover, pretreatment with various doses of THC (0.625 to 40.0 mg/kg) caused… (More)
DOI: 10.1007/BF00421433

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