The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1.

Abstract

Activation of acid-sensing ion channels (ASICs) contributes to neuronal death during stroke, to axonal degeneration during neuroinflammation, and to pain during inflammation. Although understanding ASIC gating may help to modulate ASIC activity during these pathologic situations, at present it is poorly understood. The ligand, H(+), probably binds to… (More)
DOI: 10.1074/jbc.M111.230797

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.