The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1.


Activation of acid-sensing ion channels (ASICs) contributes to neuronal death during stroke, to axonal degeneration during neuroinflammation, and to pain during inflammation. Although understanding ASIC gating may help to modulate ASIC activity during these pathologic situations, at present it is poorly understood. The ligand, H(+), probably binds to… (More)
DOI: 10.1074/jbc.M111.230797


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