The interaction between the internal clock and antidepressant efficacy.

  title={The interaction between the internal clock and antidepressant efficacy.},
  author={Giorgio Racagni and Marco Andrea Riva and Maurizio Popoli},
  journal={International clinical psychopharmacology},
  volume={22 Suppl 2},
Sleep disturbances are often associated with depression and mood disorders, and certain manipulations of the sleep-wake cycle are effective as therapeutic interventions in the treatment of depression. Dysregulated circadian rhythms are thereby considered as causal. Circadian rhythms in mammals are mainly regulated by a core biological clock, located in the hypothalamic suprachiasmatic nucleus; its pacemaker activity is regulated by light and nonphotic modulatory pathways, and the driving… CONTINUE READING


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