The interaction between tBid and cardiolipin or monolysocardiolipin.

@article{Liu2005TheIB,
  title={The interaction between tBid and cardiolipin or monolysocardiolipin.},
  author={Jihua Liu and David Durrant and H Yang and Yongwen He and Francis G Whitby and David G. Myszka and Ray M. Lee},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={330 3},
  pages={865-70}
}
Bid, a BH3-only pro-apoptotic member of the Bcl-2 family, is cleaved by caspase 8 in apoptosis induced by death domain receptors. The carboxyl terminus of the cleavage product, tBid, remains associated with the amino terminal fragment (nBid) after cleavage. Dissociation of tBid from nBid occurs during targeting of tBid to mitochondria. We use an in vitro system and demonstrate that cardiolipin is sufficient for the dissociation. Monolysocardiolipin, a metabolite of cardiolipin that increases in… CONTINUE READING

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