The interaction between prion protein and laminin modulates memory consolidation

  title={The interaction between prion protein and laminin modulates memory consolidation},
  author={A. Coitinho and A. R. Freitas and M. Lopes and G. Hajj and R. Roesler and R. Walz and J. Rossato and M. Cammarota and I. Izquierdo and V. Martins and R. Brentani},
  journal={European Journal of Neuroscience},
  • A. Coitinho, A. R. Freitas, +8 authors R. Brentani
  • Published 2006
  • Biology, Medicine
  • European Journal of Neuroscience
  • Cellular prion protein (PrPc) has a pivotal role in prion diseases. PrPc is a specific receptor for laminin (LN) γ1 peptide and several lines of evidence indicate that it is also involved in neural plasticity. Here we investigated whether the interaction between PrPc and LN plays a role in rat memory formation. We found that post‐training intrahippocampal infusion of PrPc‐derived peptides that contain the LN binding site ( and ) or of anti‐PrPc or anti‐LN antibodies that inhibit PrPc–LN… CONTINUE READING
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