The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

@article{Maurice2001TheIB,
  title={The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities},
  author={T. Maurice and A. Urani and V{\^a}n-Ly Phan and P. Romieu},
  journal={Brain Research Reviews},
  year={2001},
  volume={37},
  pages={116-132}
}
  • T. Maurice, A. Urani, +1 author P. Romieu
  • Published 2001
  • Chemistry, Medicine
  • Brain Research Reviews
  • Steroids, synthesized in peripheral glands or centrally in the brain--the latter being named neurosteroids--exert an important role as modulators of the neuronal activity by interacting with different receptors or ion channels. In addition to the modulation of GABA(A), NMDA or cholinergic receptors, neuroactive steroids interact with an atypical intracellular receptor, the sigma(1) protein. This receptor has been cloned in several species, and highly selective synthetic ligands are available… CONTINUE READING
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