The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

@article{Maurice2001TheIB,
  title={The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities},
  author={T. Maurice and A. Urani and V{\^a}n-Ly Phan and P. Romieu},
  journal={Brain Research Reviews},
  year={2001},
  volume={37},
  pages={116-132}
}
  • T. Maurice, A. Urani, +1 author P. Romieu
  • Published 2001
  • Chemistry, Medicine
  • Brain Research Reviews
    • Steroids, synthesized in peripheral glands or centrally in the brain--the latter being named neurosteroids--exert an important role as modulators of the neuronal activity by interacting with different receptors or ion channels. In addition to the modulation of GABA(A), NMDA or cholinergic receptors, neuroactive steroids interact with an atypical intracellular receptor, the sigma(1) protein. This receptor has been cloned in several species, and highly selective synthetic ligands are available… CONTINUE READING
    View on Elsevier
    doi.org
    213 Citations
    Highly Influential Citations
    15
    Background Citations
    95
    Methods Citations
    4
    Results Citations
    2
    213 Citations
    Citation Type

    Citation Type

    Neuro(active)steroids actions at the neuromodulatory sigma1 (σ1) receptor: Biochemical and physiological evidences, consequences in neuroprotection
    • 122
    Neuroactive Steroids: Receptor Interactions and Responses
    • 27
    • PDF
    The sigma1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects.
    • 157
    • PDF
    Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands
    • 287
    • Highly Influenced
    • PDF
    Neuroactive Steroids in Anxiety and Stress
    • 6
    Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways
    • 51
    • Highly Influenced
    • PDF
    Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration.
    • 21
    The cholinergic system, sigma-1 receptors and cognition
    • 77
    • PDF
    Neuroactive Steroids Protect Retinal Tissue through σ1 Receptors
    • 6
    The sigma receptor: evolution of the concept in neuropsychopharmacology.
    • 104

    References

    SHOWING 1-10 OF 131 REFERENCES
    Neuroactive neurosteroids as endogenous effectors for the sigma1 (sigma1) receptor: pharmacological evidence and therapeutic opportunities.
    • 189
    Neurosteroids: Molecular mechanisms of action and psychopharmacological significance
    • 90
    Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands
    • 189
    Stress and neurosteroids in adult and aged rats
    • 83
    Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.
    • 204
    • PDF
    Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice
    • 48
    Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors
    • 283
    • PDF
    Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor.
    • 107
    • PDF
    Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism
    • 270
    Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
    • M. Bowlby
    • Chemistry, Medicine
    • Molecular pharmacology
    • 1993
    • 201