The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.

@article{Luna2013TheIB,
  title={The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes.},
  author={Rafael Eulogio Luna and Haribabu Arthanari and Hiroyuki Hiraishi and Barak Akabayov and Leiming Tang and Christian Cox and Michelle A. Markus and Lunet E. Luna and Yuka Ikeda and Ryosuke Watanabe and Edward A Bedoya and Cathy Yu and S Liakath Alikhan and Gerhard Wagner and Katsura Asano},
  journal={Biochemistry},
  year={2013},
  volume={52 52},
  pages={9510-8}
}
Scanning of the mRNA transcript by the preinitiation complex (PIC) requires a panel of eukaryotic initiation factors, which includes eIF1 and eIF1A, the main transducers of stringent AUG selection. eIF1A plays an important role in start codon recognition; however, its molecular contacts with eIF5 are unknown. Using nuclear magnetic resonance, we unveil eIF1A's binding surface on the carboxyl-terminal domain of eIF5 (eIF5-CTD). We validated this interaction by observing that eIF1A does not bind… CONTINUE READING

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