The interaction between antidepressant drugs and the pain-relieving effect of spinal cord stimulation in a rat model of neuropathy.

@article{Song2011TheIB,
  title={The interaction between antidepressant drugs and the pain-relieving effect of spinal cord stimulation in a rat model of neuropathy.},
  author={Zhiyang Song and Bj{\"o}rn A. Meyerson and Bengt Linderoth},
  journal={Anesthesia and analgesia},
  year={2011},
  volume={113 5},
  pages={1260-5}
}
BACKGROUND Spinal cord stimulation (SCS) has proven to be a valuable treatment in neuropathic pain. On the basis of our previous studies on the mode of action of SCS, intrathecal administration of subeffective doses of certain drugs has been shown to enhance the pain-relieving effect in patients with SCS. Antidepressants have a well-established beneficial effect in neuropathic pain. We performed the present study to examine potential synergistic or antagonistic effects on SCS of antidepressants… CONTINUE READING