The interaction between TPH2 promoter haplotypes and clinical–demographic risk factors in suicide victims with major psychoses

  title={The interaction between TPH2 promoter haplotypes and clinical–demographic risk factors in suicide victims with major psychoses},
  author={V. De Luca and D. Hlousek and O. Likhodi and H. V. Van Tol and J. Kennedy and A. Wong},
Tryptophan hydroxylase isoform 2 (TPH2) is a rate‐limiting enzyme in the biosynthesis of serotonin (5‐HT) and is predominantly localized in the brain. Previous studies have suggested that there is an association between serotonergic dysfunction in the brain and suicidality. This study was designed to examine whether the −473T > A and −8396G > C polymorphisms of the TPH2 gene may be associated with completed suicide in subjects with major psychoses from the Stanley Foundation Brain Bank sample… Expand
31 Citations
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