The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.

@article{Chung1996TheIB,
  title={The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.},
  author={Ung-il Chung and Takashi Igarashi and Toshihide Nishishita and Hiroko Iwanari and Akihiro Iwamatsu and Akira Suwa and Tsuneyo Mimori and Keiko Hata and Shogo Ebisu and Etsuro Ogata and Takashi Fujita and Toshiro Okazaki},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 15},
  pages={8593-8}
}
Through the specific binding of a negative calcium-responsive element to its binding protein in response to extracellular Ca (Ca2+e), negative calcium-responsive element-bearing genes, such as the human parathyroid hormone gene, are negatively regulated by Ca2+e. The Ku antigen mediated negative gene regulation by Ca2+e by interacting with a redox factor protein, REF1. Although sequence-nonspecific DNA binding activity of the Ku antigen has been well characterized, the mechanism of its sequence… CONTINUE READING

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