The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish.

@article{Pluskota2011TheIC,
  title={The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish.},
  author={Elzbieta Pluskota and James J Dowling and Natalie K Gordon and Jeffrey Alan Golden and Dorota Szpak and Xiaoxia Z. West and Carla Nestor and Yan-Qing Ma and Katarzyna Bialkowska and Tatiana V. Byzova and Edward F Plow},
  journal={Blood},
  year={2011},
  volume={117 18},
  pages={4978-87}
}
Kindlin-2, a widely distributed cytoskeletal protein, has been implicated in integrin activation, and its absence is embryonically lethal in mice and causes severe developmental defects in zebrafish. Knockdown of kindlin-2 levels in endothelial cells resulted in defective adhesive and migratory responses, suggesting that angiogenesis might be aberrant even with partial reduction of kindlin-2. This hypothesis has now been tested in the kindlin-2(+/-) mice. RM1 prostate tumors grown in kindlin-2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…