The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

Abstract

Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin alpha(4)beta(7) (alpha(4)beta(7)), the gut mucosal homing receptor. We find that alpha(4)beta(7)(high) CD4(+) T cells are more susceptible to productive infection than are alpha(4)beta(7)(low-neg) CD4(+) T cells in part because this cellular subset is enriched with metabolically active CD4(+) T cells. alpha(4)beta(7)(high) CD4(+) T cells are CCR5(high) and CXCR4(low); on these cells, alpha(4)beta(7) appears in a complex with CD4. The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.

DOI: 10.1073/pnas.0911796106
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@article{Cicala2009TheIA, title={The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.}, author={Claudia Cicala and Elena Martinelli and Jonathan P. McNally and Diana J. Goode and Ravindra Gopaul and Joseph Hiatt and Katija Jelicic and Shyamasundaran Kottilil and Katilyn Macleod and Angeline O'shea and Nikita Patel and Donald I Van Ryk and Danlan Wei and Massimiliano Pascuccio and Ling Ka Yi and Lyle McKinnon and Preson Izulla and Joshua Kimani and Rupert Kaul and Anthony S . Fauci and James A. Arthos}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2009}, volume={106 49}, pages={20877-82} }