The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation.

@article{Sandoval2008TheIR,
  title={The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation.},
  author={Darleen A Sandoval and Daniela Cota and Randy J Seeley},
  journal={Annual review of physiology},
  year={2008},
  volume={70},
  pages={513-35}
}
The incidences of both obesity and type 2 diabetes mellitus are rising at epidemic proportions. Despite this, the balance between caloric intake and expenditure is tremendously accurate under most circumstances. Growing evidence suggests that nutrient and hormonal signals converge and directly act on brain centers, leading to changes in fuel metabolism and, thus, stable body weight over time. Growing evidence also suggests that these same signals act on the central nervous system (CNS) to… CONTINUE READING
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