The integrative management of treatment-resistant depression: a comprehensive review and perspectives.


BACKGROUND Major depressive disorder is a prevalent and disabling illness. Notwithstanding numerous advances in the pharmacological treatment of depression, approximately 70% of patients do not remit after first-line antidepressant treatment. METHODS The MEDLINE/PubMed, EMBASE and electronic databases were searched from inception to… (More)
DOI: 10.1159/000357500