The integration of cell and chemical biology in protein folding.

@article{Kelly2006TheIO,
  title={The integration of cell and chemical biology in protein folding.},
  author={Jeffery W Kelly and William Edward Balch},
  journal={Nature chemical biology},
  year={2006},
  volume={2 5},
  pages={224-7}
}
Eukaryotic cells are specialized, interdependent functional units of complex tissues that are composed of metabolically integrated systems defined by chemically distinct organelles that operate as reaction vessels. It is now clear that the small-molecule and polymer-based composition of these organelles plays a crucial role in generating and maintaining protein folds and functions through the systems chemistry of the local environments. 

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