The insulin resistance syndrome: definition and dietary approaches to treatment.

@article{Reaven2005TheIR,
  title={The insulin resistance syndrome: definition and dietary approaches to treatment.},
  author={Gerald Reaven},
  journal={Annual review of nutrition},
  year={2005},
  volume={25},
  pages={
          391-406
        }
}
  • G. Reaven
  • Published 12 July 2005
  • Medicine
  • Annual review of nutrition
The ability of insulin to stimulate glucose disposal varies at least sixfold in apparently healthy individuals, and approximately one-third of the population that is most resistant to this action of insulin is at greatly increased risk to develop a number of adverse clinical outcomes. Type 2 diabetes occurs when insulin resistant individuals are unable to secrete enough insulin to compensate for the defect in insulin action, and this was the first clinical syndrome identified as being related… 

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References

SHOWING 1-10 OF 65 REFERENCES

The kidney: an unwilling accomplice in syndrome X.

  • G. Reaven
  • Medicine
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1997

Role of Insulin Resistance in Human Disease

The possibility is raised that resistance to insulin-stimulated glucose uptake and hyperinsulinemia are involved in the etiology and clinical course of three major related diseases— NIDDM, hypertension, and CAD.

Reduced insulin secretion: an independent predictor of body weight gain.

It is concluded that insulin resistance and hyperinsulinemia are unlikely to play a causal role in the development of obesity, and that relatively reduced insulin secretion is a marker of an increased risk of weight gain in this population of Pima Indians.

Use of Metabolic Markers To Identify Overweight Individuals Who Are Insulin Resistant

The prevalence of insulin resistance is increased in patients with type 2 diabetes mellitus, essential hypertension, and CVD and that insulin resistance and compensatory hyperinsulinemia have been shown to be independent predictors of all 3 clinical syndromes.

Differences in insulin resistance do not predict weight loss in response to hypocaloric diets in healthy obese women.

It is concluded that the ability to lose weight on a calorie-restricted diet over a short time period does not vary in obese, healthy women as a function of insulin resistance or hyperinsulinemia.

Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome

PCO women have significant insulin resistance that is independent of obesity, changes in body composition, and impairment of glucose tolerance, and PCO is associated with a unique disorder of insulin action.

Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects.

Considerable controversy exists over the purported role of obesity in causing hyperglycemia, hyperlipemia, hyperinsulinemia, and insulin resistance; and the potential beneficial effects of weight

Insulin resistance as a predictor of age-related diseases.

The fact that an age-related clinical event developed in approximately 1 out of 3 healthy individuals in the upper tertile of insulin resistance at baseline, followed for an average of 6 yr, whereas no clinical events were observed in the most insulin-sensitive tertile, should serve as a strong stimulus to further efforts to define the role of insulin Resistance in the genesis of age- related diseases.
...