The insulin resistance syndrome: definition and dietary approaches to treatment.

@article{Reaven2005TheIR,
  title={The insulin resistance syndrome: definition and dietary approaches to treatment.},
  author={Gerald Reaven},
  journal={Annual review of nutrition},
  year={2005},
  volume={25},
  pages={
          391-406
        }
}
  • G. Reaven
  • Published 12 July 2005
  • Medicine
  • Annual review of nutrition
The ability of insulin to stimulate glucose disposal varies at least sixfold in apparently healthy individuals, and approximately one-third of the population that is most resistant to this action of insulin is at greatly increased risk to develop a number of adverse clinical outcomes. Type 2 diabetes occurs when insulin resistant individuals are unable to secrete enough insulin to compensate for the defect in insulin action, and this was the first clinical syndrome identified as being related… 

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