The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones?

@article{Fernando2008TheIA,
  title={The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus--potential role in modulation of glucose uptake in neurones?},
  author={Ruani N Fernando and Anthony Lloyd Albiston and S. Y. Chai},
  journal={The European journal of neuroscience},
  year={2008},
  volume={28 3},
  pages={
          588-98
        }
}
It is proposed that insulin-regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV-hemorphin 7, which have facilitatory effects on learning and memory. In fat and muscles, IRAP codistributes with the insulin-responsive glucose transporter GLUT4 in specialised vesicles, where it plays a role in the tethering and/or trafficking of these vesicles. This study investigated whether an analogous system exists in two functionally distinct regions of the brain, the… CONTINUE READING
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Journal Compilation a Federation of European Neuroscience Societies and Blackwell Publishing Ltd

  • R. N. Fernando
  • 2008

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