The insulin paradox: aging, proteotoxicity and neurodegeneration

  title={The insulin paradox: aging, proteotoxicity and neurodegeneration},
  author={Ehud Cohen and Andrew G Dillin},
  journal={Nature Reviews Neuroscience},
Distinct human neurodegenerative diseases share remarkably similar temporal emergence patterns, even though different toxic proteins are involved in their onset. Typically, familial neurodegenerative diseases emerge during the fifth decade of life, whereas sporadic cases do not exhibit symptoms earlier than the seventh decade. Recently, mechanistic links between the aging process and toxic protein aggregation, a common hallmark of neurodegenerative diseases, have been revealed. The insulin… CONTINUE READING
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