The insulin-like growth factor system and sarcomas.

  title={The insulin-like growth factor system and sarcomas.},
  author={Bart Rikhof and Steven de Jong and Albert J Suurmeijer and Coby Meijer and Winette T. A. van der Graaf},
  journal={The Journal of pathology},
  volume={217 4},
Sarcomas are a diverse group of malignant mesenchymal tumours arising from bone and soft tissues. The identification of critical cellular signalling pathways in sarcomas is an important issue for the development of new targeted therapies. This review highlights the experimental and clinical evidence supporting the role of the insulin-like growth factor (IGF) signalling system in the cellular transformation and progression of several types of sarcoma, including rhabdomyosarcoma, synovial sarcoma… CONTINUE READING


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