The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis.

@article{Werner1997TheIG,
  title={The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis.},
  author={Haim Werner and Derek Le Roith},
  journal={Critical reviews in oncogenesis},
  year={1997},
  volume={8 1},
  pages={71-92}
}
The biological actions of the insulin-like growth factors IGF-I and IGF-II are mediated by their activation of the IGF-IR, a transmembrane tyrosine kinase linked to the ras-raf-MAPK cascade. Functional IGF-IRs are required for the cell to progress through the cell cycle. Most importantly, cells lacking this receptor cannot be transformed by any of a number of dominant oncogenes, a finding that proves that the presence of the IGF-IR is important for the development of a malignant phenotype… CONTINUE READING