The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs

@article{Hoopes2012TheIG,
  title={The insulin-like growth factor 1 receptor (IGF1R) contributes to reduced size in dogs},
  author={Barbara C. Hoopes and Maud Rimbault and David T Liebers and Elaine A Ostrander and Nathan B. Sutter},
  journal={Mammalian Genome},
  year={2012},
  volume={23},
  pages={780-790}
}
Domestic dog breeds have undergone intense selection for a variety of morphologic features, including size. Among small-dog breeds, defined as those averaging less than ~15 in. at the withers, there remains still considerable variation in body size. Yet essentially all such dogs are fixed for the same allele at the insulin-like growth factor 1 gene, which we and others previously found to be a size locus of large effect. In this study we sought to identify additional genes that contribute to… CONTINUE READING
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