The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy.

@article{Bhr2004TheIL,
  title={The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy.},
  author={Corinna B{\"a}hr and Bernd Groner},
  journal={Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  year={2004},
  volume={14 4},
  pages={287-95}
}
The insulin-like growth factor 1 receptor (IGF-1R) is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF-1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. Different classes of molecules, e.g., antisense RNA, monoclonal antibodies and dominant negative IGF-1R gene variants, have been employed towards this aim. These agents… CONTINUE READING
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