The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity

@article{Stunff2000TheIG,
  title={The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity},
  author={Catherine L E Stunff and Dani{\`e}le Fallin and Nicholas J. Schork and Pierre Bougn{\`e}res},
  journal={Nature Genetics},
  year={2000},
  volume={26},
  pages={444-446}
}
In millions of people, obesity leads to type 2 diabetes (T2D; also known as non-insulin-dependent diabetes mellitus). During the early stages of juvenile obesity, the increase of insulin secretion in proportion to accumulated fat balances insulin resistance and protects patients from hyperglycaemia. After several decades, however, β-cell function deteriorates and T2D develops in approximately 20% of obese patients. In modern societies, obesity has thus become the leading risk factor for T2D… CONTINUE READING
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