The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents.

@article{CeltonMorizur2009TheIP,
  title={The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents.},
  author={S{\'e}verine Celton-Morizur and Gr{\'e}gory Merlen and Dominique Couton and Germain Margall-Ducos and Chantal Desdouets},
  journal={The Journal of clinical investigation},
  year={2009},
  volume={119 7},
  pages={1880-7}
}
The formation of polyploid cells is part of the developmental program of several tissues. During postnatal development, binucleated tetraploid cells arise in the liver, caused by failure in cytokinesis. In this report, we have shown that the initiation of cytokinesis failure events and the subsequent appearance of binucleated tetraploid cells are strictly controlled by the suckling-to-weaning transition in rodents. We found that daily light/dark rhythms and carbohydrate intake did not affect… CONTINUE READING

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