The insula–claustrum region and delusions in schizophrenia

@article{Cascella2011TheIR,
  title={The insula–claustrum region and delusions in schizophrenia},
  author={Nicola Cascella and Gwendolyn J. Gerner and Shaina Clavelle Fieldstone and Akira Sawa and David J. Schretlen},
  journal={Schizophrenia Research},
  year={2011},
  volume={133},
  pages={77-81}
}
OBJECTIVE We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions. RESULTS The analysis revealed significant inverse correlations between ratings of the severity of delusions and volumes of the left claustrum and right insula. Significant… 
Decreased Left Putamen and Thalamus Volume Correlates with Delusions in First-Episode Schizophrenia Patients
TLDR
Left putamen and thalamus volume loss may be biological correlates of delusions in schizophrenia and inter-group differences in gray matter volume are explored.
The Claustrum in Schizophrenia
Schizophrenia is characterized by three partially overlapping domains of symptoms: positive, negative and disorganized. With the advent of neuroimaging techniques, attempts have been made to
Neural substrates underlying delusions in schizophrenia
TLDR
It is suggested that schizophrenia patients with severe delusions have relatively normal structural integrity, and the excessively reduced perfusion in the anterior cingulate cortex may be associated with the development of delusions in schizophrenia.
A New Perspective on Delusional States – Evidence for Claustrum Involvement
TLDR
A novel hypothesis and extant supporting evidence are presented implicating the claustrum, a relatively poorly understood forebrain nucleus, as a potential common center for delusional states.
Cortical salience network activation precedes the development of delusion severity
TLDR
Activation of CSN (‘illness evaluation v. control task’ contrast) in patients positively correlated with worsening of or less improvement in delusions at the 2-month follow-up assessment, independent of delusion and clinical insight scores.
Bilaterally reduced claustral volumes in schizophrenia and major depressive disorder: a morphometric postmortem study
TLDR
Bilaterally reduced claustral volumes are found both in schizophrenia and in major depressive disorder.
Reduced cortical thickness in right Heschl’s gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia
TLDR
Abnormalities of cortical thickness in the Heschl’s gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.
Laterality interacts with sex across the schizophrenia/bipolarity continuum: An interpretation of meta-analyses of structural MRI
TLDR
Brain structures implicated in schizophrenia include those implicated in bipolar disorder, and structural change underlying the continuum of psychosis relates to the interaction of laterality and sex.
Decreased Functional Connectivity of Insular Cortex in Drug Na ï ve First Episode Schizophrenia : In Relation to Symptom Severity
Background This study was to examine the insular cortical functional connectivity in drug naïve patients with first episode schizophrenia and to explore the relationship between the connectivity and
The development of delusion revisited: A transdiagnostic framework
TLDR
A transdiagnostic framework for delusion development is proposed, analysing psychiatric and neurological disorders and suggests that common neural mechanisms for the delusions in psychiatric and in neurological disorders.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia.
TLDR
The authors' MRI study of young schizophrenic patients demonstrates smaller volume of the superior temporal gyrus and of the left amygdala, which is not accounted for by smaller size of the overall brain or temporal lobe.
Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure
TLDR
There were no significant differences in morphology between patients and control subjects; however, among patients, psychotic symptoms were inversely correlated with insular volume, replicating the previous finding in neuroleptic-naive subjects.
Gray matter abnormalities in paranoid schizophrenia and their clinical correlations
TLDR
The results suggest the important roles of the paralimbic structures in the pathophysiology of schizophrenia and the involvement of the perceptual and monitoring systems in the mechanism of insight.
Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study
TLDR
Voxel-wise correlations with a score of auditory hallucination severity identified areas in the left and right superior temporal cortex (including Heschl's gyrus), left supramarginal/angular gyrus, left postcentral gyrus and left posterior cingulate cortex.
The role of the insula in schizophrenia
TLDR
The normal function of the insula is described and pathology of this region in schizophrenia is examined, suggesting that insula dysfunction may contribute to hallucinations, a cardinal feature of schizophrenia.
A computational morphometric MRI study of schizophrenia: effects of hallucinations.
TLDR
MRI data confirm the utility of voxel-based morphometric methods in schizophrenia research and point towards disruption to a 'paralimbic' neural network, as underlying schizophrenic psychopathology in general, with abnormalities of the left insula specifically related to hallucinations.
Volumetric MRI study of the short and long insular cortices in schizophrenia spectrum disorders
TLDR
The results suggest that the volume reduction of the insular cortex may be specific to overt schizophrenia without topographically specific localization.
Insular cortex abnormalities in schizophrenia: a structural magnetic resonance imaging study of first-episode patients
TLDR
Insular gray matter volume and cortical surface size correlated negatively and significantly with the psychotic symptom dimension and the role of the insula in the pathophysiology of schizophrenia is evaluated.
Activation of Heschl’s Gyrus during Auditory Hallucinations
TLDR
An experiment with paranoid schizophrenic patients whose on- and offset of auditory hallucinations could be monitored within one functional magnetic resonance imaging (fMRI) session is described, demonstrating an increase of the blood oxygen level-dependent (BOLD) signal in Heschl's gyrus during the patients' hallucinations.
Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia
TLDR
The data corroborate and extend previous findings of temporolimbic structure volume reduction in schizophrenia, and suggest that the positive psychotic symptoms of schizophrenia are associated with anatomic anomalies in mesiotemporal structure.
...
1
2
3
4
...