The insider's guide to leukocyte integrin signalling and function

@article{Hogg2011TheIG,
  title={The insider's guide to leukocyte integrin signalling and function},
  author={N. Hogg and Irene Patzak and F. Willenbrock},
  journal={Nature Reviews Immunology},
  year={2011},
  volume={11},
  pages={416-426}
}
The activation of leukocyte integrins through diverse receptors results in transformation of the integrin from a bent, resting form to an extended conformation, which has at least two states of ligand-binding activity. This highly regulated activation process is essential for T cell migration and the formation of an immunological synapse. The signalling events that drive integrin activation are complex. Some key players have been well-characterized, but other aspects of the signalling… Expand
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