The insertion of an anti-MHC I ScFv into the N-terminus of an ecotropic MLV glycoprotein does not alter its fusiogenic potential on murine cells.

Abstract

It is known that targeted infection requires the modification of the viral envelope, in order to render it capable of recognizing and specifically binding to a marker protein of the target cell. We have previously described such a recombinant envelope, which is able to extend the tropism of an ecotropic murine leukemia viruses (MLV) envelope to MHC I… (More)

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