The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio).

  title={The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio).},
  author={M{\'e}lanie Le Blanc and Philipp Antczak and Xavier Cousin and Christoph Grunau and Nikolai Scherbak and Jo{\"e}lle R{\"u}egg and Steffen H. Keiter},
  journal={The Science of the total environment},
4 Citations
Multigenerational effects modify the tolerance of mosquito larvae to chlorpyrifos but not to a heat spike and do not change their synergism.
The results provide important evidence that short exposure to pulse-like global change stressors can strongly affect organisms within and across generations, and highlight the importance of considering multigenerational effects in risk assessment.
Ozonolysis of Permethrin in the Atmosphere: Mechanism, Kinetics, and Evaluation of Toxicity.
The results show that ozonolysis products of PER are still extremely harmful to the environment and should be taken seriously, although the products have less toxicity than PER, and the quantitative structure and activity relationship is predicted.
Endocrine Disruptors in Freshwater: Impact on Teleost Reproduction
  • Shelley Bhattacharya, C. Munshi
  • Proceedings of the Zoological Society
  • 2021


Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47: Impact on growth, fertility, behavior and lipid metabolism.
It is found that behavior of zebrafish larvae was significantly affected by exposure to permethrin in F1 to F3 generations with some differences depending on the concentration, which suggests persistent alteration of the neural or neuromuscular function.
Transgenerational effects of developmental exposure to chlorpyrifos-oxon in zebrafish (DANIO RERIO).
Results from this study demonstrate that early life stage exposures to CPO can lead to epigenetic changes in neurological activity, which may lead to alterations in response to C PO in future generations.
Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations.
Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures.
Exposure to low doses of inorganic arsenic induces transgenerational changes on behavioral and epigenetic markers in zebrafish (Danio rerio).
Arsenic exposure altered motor activity through the development and increased anxiety-like behaviors which were transmitted to the F2 generation, and a reduction in brain-derived neurotrophic factor expression and an increase in methylation on histone H3K4me3 in the nervous system were found.
Intergenerational Effect of Early Life Exposure to Permethrin: Changes in Global DNA Methylation and in Nurr1 Gene Expression
An intergenerational PERM-induced damage on progenies has been identified for the first time in rats exposed in early life to Permethrin.
Acute Exposure to Permethrin Modulates Behavioral Functions, Redox, and Bioenergetics Parameters and Induces DNA Damage and Cell Death in Larval Zebrafish
The results demonstrated the adverse effects of acute sublethal PM concentrations during larval development in zebrafish, causing apparent mitochondrial dysfunction, indicating a potential mechanism to redox unbalance and oxidative stress, which may be linked to the detected cell death and alterations in normal behavior patterns caused by acute PM exposure.
Environmentally relevant levels of λ-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo.
Findings suggest that these 3 SPs may cause developmental toxicity to zebrafish larvae by disrupting endocrine signaling at environmentally relevant concentrations.
Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures
Exposure-specific epigenetic biomarkers were identified that may allow for the assessment of ancestral environmental exposures associated with adult onset disease.
Acute embryonic exposure of zebrafish to permethrin induces behavioral changes related to anxiety and aggressiveness in adulthood.
It is demonstrated that embryonic exposure to PM induces persistent neurotoxic effects in adulthood, which can impair the cognitive and behavioral fitness of non-target species contributing to a rise in neurodevelopmental disorders.
Examining multi- and transgenerational behavioral and molecular alterations resulting from parental exposure to an environmental PCB and PBDE mixture.
It is hypothesized that chronic dietary exposure to an environmentally relevant mixture of PCB and PBDE triggers multigenerational and transgenerational molecular and behavioral disruptions in a vertebrate model.