The insect-specific Palm Creek virus modulates West Nile virus infection in and transmission by Australian mosquitoes

@article{HallMendelin2016TheIP,
  title={The insect-specific Palm Creek virus modulates West Nile virus infection in and transmission by Australian mosquitoes},
  author={S. Hall-Mendelin and Breeanna J. McLean and H. Bielefeldt-Ohmann and J. Hobson-Peters and R. Hall and A. F. van den Hurk},
  journal={Parasites \& Vectors},
  year={2016},
  volume={9}
}
BackgroundInsect-specific viruses do not replicate in vertebrate cells, but persist in mosquito populations and are highly prevalent in nature. These viruses may naturally regulate the transmission of pathogenic vertebrate-infecting arboviruses in co-infected mosquitoes. Following the isolation of the first Australian insect-specific flavivirus (ISF), Palm Creek virus (PCV), we investigated routes of infection and transmission of this virus in key Australian arbovirus vectors and its impact on… Expand
Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes
Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.Expand
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References

SHOWING 1-10 OF 46 REFERENCES
Transmission dynamics of an insect-specific flavivirus in a naturally infected Culex pipiens laboratory colony and effects of co-infection on vector competence for West Nile virus.
TLDR
It is found that vertical transmission is the primary mechanism for persistence of CxFV in Cx. Expand
A New Insect-Specific Flavivirus from Northern Australia Suppresses Replication of West Nile Virus and Murray Valley Encephalitis Virus in Co-infected Mosquito Cells
TLDR
It is demonstrated that prior infection of cultured mosquito cells with PCV suppressed subsequent replication of the medically significant West Nile and Murray Valley encephalitis viruses by 10–43 fold, suggesting that superinfection exclusion can occur between ISFs and vertebrate-infecting flaviviruses despite their high level of genetic diversity. Expand
The Impact of Wolbachia on Virus Infection in Mosquitoes
TLDR
Research on the prevalence of Wolbachia in mosquito vector species and the impact of antiviral effects in both naturally and artificially Wolbachio-infected mosquitoes is outlined. Expand
Potential for Co-Infection of a Mosquito-Specific Flavivirus, Nhumirim Virus, to Block West Nile Virus Transmission in Mosquitoes
TLDR
Data indicate the potential that infection of some Culex spp. Expand
A novel insect-specific flavivirus replicates only in Aedes-derived cells and persists at high prevalence in wild Aedes vigilax populations in Sydney, Australia.
TLDR
Investigation of the diversity and prevalence of ISFs in Australian mosquitoes, samples from various regions were screened for flaviviruses by ELISA and RT-PCR and revealed PaRV had persisted in A. vigilax populations in Sydney, with 88% of pools positive. Expand
Role of enhanced vector transmission of a new West Nile virus strain in an outbreak of equine disease in Australia in 2011
TLDR
The higher amount of W NVKUN2011 expectorated by infected mosquitoes may be an indication that this virus strain is transmitted more efficiently by Cx. Expand
Vector Competence of California Mosquitoes for West Nile virus
TLDR
Culex species are likely to play the primary role in the enzootic maintenance and transmission of WNV in California, and Cx. Expand
Emerging tropical diseases in Australia. Part 4. Mosquitoborne diseases
TLDR
The trends, threats and challenges that face the management of mosquito-borne disease in Australia, including West Nile, chikungunya and Rift Valley fever viruses, and the introduction of exotic vectors, are discussed. Expand
West Nile virus dissemination and tissue tropisms in orally infected Culex pipiens quinquefasciatus.
TLDR
Insight is provided into WNV infection dynamics in a highly susceptible, epidemiologically important, North American vector and the results pave the way for future studies to analyze physical and biological barriers to WNV dissemination in less competent mosquitoes. Expand
RNAi Targeting of West Nile Virus in Mosquito Midguts Promotes Virus Diversification
TLDR
It is demonstrated that WNV infection in orally exposed vector mosquitoes induces the RNAi pathway and that regions of the WNV genome that are more intensely targeted by RNAi are more likely to contain point mutations compared to weakly targeted regions. Expand
...
1
2
3
4
5
...