The ins and outs of serine integrase site-specific recombination.

@article{Rutherford2014TheIA,
  title={The ins and outs of serine integrase site-specific recombination.},
  author={Karen Rutherford and Gregory D Van Duyne},
  journal={Current opinion in structural biology},
  year={2014},
  volume={24},
  pages={125-31}
}
Serine integrases catalyze the integration and excision of phage genomes into and out of bacterial chromosomes in a highly specific and directional manner, making these proteins powerful tools for genome engineering. In 2013, the first structure of a serine integrase-DNA complex was reported. This work revealed how the phage attP sequence is recognized by the integrase and provided important clues about how serine integrases bind to other attachment site sequences. The resulting structural… CONTINUE READING

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