The ins and outs of gene regulation and chromosome territory organisation.

@article{Heard2007TheIA,
  title={The ins and outs of gene regulation and chromosome territory organisation.},
  author={Edith Heard and W. Bickmore},
  journal={Current opinion in cell biology},
  year={2007},
  volume={19 3},
  pages={311-6}
}
The establishment and maintenance of differential patterns of gene expression lie at the heart of development. How the precision of developmental gene regulation is achieved, despite the highly repetitive and complex nature of the mammalian genome, remains an important question. It is becoming increasingly clear that genetic regulation must be considered not only in the context of short- and long-range regulatory sequences and local chromatin structure, but also at the level of position within… CONTINUE READING

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Nuclear re - organisation and chromatin decondensation are conserved , but distinct , mechanisms linked to Hox gene activation

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A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced

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