The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.

@article{vanderHeide2004TheIA,
  title={The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.},
  author={Lars P. van der Heide and Marco F. M. Hoekman and Marten P. Smidt},
  journal={The Biochemical journal},
  year={2004},
  volume={380 Pt 2},
  pages={
          297-309
        }
}
FoxO (forkhead box O; forkhead members of the O class) are transcription factors that function under the control of insulin/insulin-like signalling. FoxO factors have been associated with a multitude of biological processes, including cell-cycle, cell death, DNA repair, metabolism and protection from oxidative stress. Central to the regulation of FoxO factors is a shuttling system, which confines FoxO factors to either the nucleus or the cytosol. Shuttling of FoxO requires protein… 

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TLDR
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