The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
@article{vanderHeide2004TheIA, title={The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.}, author={Lars P. van der Heide and Marco F. M. Hoekman and Marten P. Smidt}, journal={The Biochemical journal}, year={2004}, volume={380 Pt 2}, pages={ 297-309 } }
FoxO (forkhead box O; forkhead members of the O class) are transcription factors that function under the control of insulin/insulin-like signalling. FoxO factors have been associated with a multitude of biological processes, including cell-cycle, cell death, DNA repair, metabolism and protection from oxidative stress. Central to the regulation of FoxO factors is a shuttling system, which confines FoxO factors to either the nucleus or the cytosol. Shuttling of FoxO requires protein…
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