The inotropic effects of a synthetic pyrethroid decamethrin on isolated guinea pig atrial muscle.

@article{Berlin1984TheIE,
  title={The inotropic effects of a synthetic pyrethroid decamethrin on isolated guinea pig atrial muscle.},
  author={Joshua R Berlin and Tai Akera and Theodore M. Brody and Fuseo Matsumura},
  journal={European journal of pharmacology},
  year={1984},
  volume={98 3-4},
  pages={313-22}
}
Pyrethroid insecticides have been reported to increase transmembrane sodium influx and inhibit ion-dependent ATPases in insect, squid, and toad nerve tissues. Since changes in sarcolemmal ion fluxes and inhibition of membrane-bound ATPases can alter myocardial contractility, the effects of a potent synthetic pyrethroid, decamethrin, on mammalian myocardium were examined using isolated left atrial muscle of the guinea-pig heart electrically stimulated at 1.5 Hz. Decamethrin (0.1-10 microM… CONTINUE READING

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