The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function.

@article{Altamirano2006TheIE,
  title={The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function.},
  author={Julio Altamirano and Yanxia Li and Jaime Desantiago and Valentino Piacentino and Steven R. Houser and Donald M. Bers},
  journal={The Journal of physiology},
  year={2006},
  volume={575 Pt 3},
  pages={845-54}
}
Glycoside-induced cardiac inotropy has traditionally been attributed to direct Na(+)-K(+)-ATPase inhibition, causing increased intracellular [Na(+)] and consequent Ca(2+) gain via the Na(+)-Ca(2+) exchanger (NCX). However, recent studies suggested alternative mechanisms of glycoside-induced inotropy: (1) direct activation of sarcoplasmic reticulum Ca(2+) release channels (ryanodine receptors; RyRs); (2) increased Ca(2+) selectivity of Na(+) channels (slip-mode conductance); and (3) other signal… CONTINUE READING
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