The inositol phosphate pathway as a mediator in the proliferative response of rat calvarial bone cells to cyclical biaxial mechanical strain.

Abstract

Isolated newborn rat calvarial bone cells grown in monolayer on polyurethane membranes in specially constructed culture chambers and subjected to a cyclical biaxial mechanical strain of 0.17% at a frequency of 1 Hz for 30 min demonstrated a 16% increase in DNA synthesis during the subsequent 24 h. The metabolites of the inositol phosphate pathway, shown to… (More)

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@article{Brighton1992TheIP, title={The inositol phosphate pathway as a mediator in the proliferative response of rat calvarial bone cells to cyclical biaxial mechanical strain.}, author={Carl T. Brighton and Brian Sennett and James C. Farmer and Joseph P. Iannotti and Carl A. Hansen and Jade L Williams and Joann Williamson}, journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society}, year={1992}, volume={10 3}, pages={385-93} }