The inositol phosphate/diacylglycerol signalling pathway in Trypanosoma cruzi.

@article{Docampo1991TheIP,
  title={The inositol phosphate/diacylglycerol signalling pathway in Trypanosoma cruzi.},
  author={Roberto Docampo and Omar Pedro Pignataro},
  journal={The Biochemical journal},
  year={1991},
  volume={275 ( Pt 2)},
  pages={407-11}
}
Using [32P]Pi and [3H]inositol as precursors, we have detected the presence of phosphatidylinositol, phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate, and their derivatives inositol phosphate, inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate respectively, in Trypanosoma cruzi epimastigotes. Using digitonin-permeabilized cells it was possible to detect a stimulation in the formation of inositol 1,4,5-trisphosphate and inositol 1,4-bisphosphate as well as an… CONTINUE READING