The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells.

  title={The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells.},
  author={M Javad Aman and T D Lamkin and Hidetaka Okada and Tomohiro Kurosaki and Kodi Ravichandran},
  journal={The Journal of biological chemistry},
  volume={273 51},
The serine-threonine kinase Akt/PKB is activated downstream of phosphatidylinositol 3-kinase in response to several growth factor stimuli and has been implicated in the promotion of cell survival. Although both phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,4-bisphosphate (PI 3,4-P2) have been implicated in the regulation of Akt activity in vitro, the relative roles of these two phospholipids in vivo are not well understood. Co-ligation of the B cell receptor (BCR… CONTINUE READING
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