The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.

@article{Baran2003TheI5,
  title={The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.},
  author={Christopher P. Baran and Susheela Tridandapani and Cheryl D. Helgason and Richard Keith Humphries and Gerald Krystal and Clay B. Marsh},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 40},
  pages={38628-36}
}
Upon encountering macrophage colony-stimulating factor (M-CSF), human monocytes undergo a series of cellular signaling events leading to an increase in Akt activity. However, the regulation of these events is not completely understood. Because the inositol 5'-phosphatase SHIP-1 is an important regulator of intracellular levels of phosphatidylinositol 3,4,5-trisphosphate, an important second messenger necessary for Akt activation, we hypothesized that SHIP-1 was involved in the regulation of M… CONTINUE READING

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