The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

@article{Vicencio2009TheI1,
  title={The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1},
  author={Jos{\'e} Miguel Vicencio and Conrad Ortiz and Alfredo Criollo and Aleck W. E. Jones and Oliver Kepp and Lorenzo Galluzzi and Nicholas A. Joza and Ilio Vitale and Eugenia Morselli and Maximilien Tailler and Maria Castedo and Maria Chiara Maiuri and Jordi Molg{\'o} and Gyorgy Szabadkai and Sergio Lavandero and Guido Kroemer},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={1006-1017}
}
The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic reticulum (ER) to mitochondria, thereby establishing a functional and physical link between these organelles. Importantly, the IP3R also regulates autophagy, and in particular, its inhibition/depletion strongly induces macroautophagy. Here, we show that the IP3R antagonist… CONTINUE READING
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