The inorganic side of chemical biology

  title={The inorganic side of chemical biology},
  author={Stephen J. Lippard},
  journal={Nature Chemical Biology},
  • S. Lippard
  • Published 1 October 2006
  • Chemistry
  • Nature Chemical Biology
Bioinorganic chemistry remains a vibrant discipline at the interface of chemistry and the biological sciences. Metal ions function in numerous metalloenzymes, are incorporated into pharmaceuticals and imaging agents, and inspire the synthesis of catalysts used to achieve many chemical transformations. 
Palladium-mediated intracellular chemistry.
P palladium nanoparticles trapped within polystyrene microspheres can enter cells and mediate a variety of Pd(0)-catalysed reactions, such as allylcarbamate cleavage and Suzuki-Miyaura cross-coupling, providing the basis for the customization of heterogeneous unnatural catalysts as tools to carry out artificial chemistries within cells.
Introducing Metallosalens into Biological Studies: The Renaissance of Traditional Coordination Complexes
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Transition metal-promoted biomimetic steps in total syntheses.
This review summarizes the state-of-the-art on the use of transition metals in synthetic steps inspired by biosynthesis. After an introduction showing the importance of metals in life processes, with
Modelling Binuclear Metallobiosites: Insights from Pyrazole‐Supported Biomimetic and Bioinspired Complexes
Numerous enzymes use two closely spaced metal ions to activate and transform small molecules. This allows these biocatalysts to perform diverse physiological functions, achieving impressive chemistry
The Ferrocifen Family as Potent and Selective Antitumor Compounds: Mechanisms of Action
Chemical Biology, a discipline that links chemical engineering and biology, differs from biochemistry by positioning itself as a broad chemical domain that makes available to biology the tools and
Bioactive luminescent transition-metal complexes for biomedical applications.
This Review highlights recent examples of biologically active luminescent metal complexes that can target and probe a specific biomolecule, and offers insights into the future potential of these compounds for the investigation and treatment of human diseases.
Oxygen dissociation by concerted action of di-iron centers in metal-organic coordination networks at surfaces: modeling non-heme iron enzymes.
The high structural flexibility of the organic ligands, the mobility of the metal centers, and the hydrogen bonding formation are shown to be essential for the functionality of these active centers allowing to mimick biologically relevant reactions in a confined environment.


Principles Of Bioinorganic Chemistry
An Overview of Bioinorganic Chemistry Principles of Coordination Chemistry Related to Bioinorganic Research Properties of Biological Molecules Physical Methods in Bioinorganic Chemistry Choice and
The origins of chemical biology
Chemical biology has historical roots that date back to the birth of chemistry and biology as distinct sciences, as well as other sciences, up to and including modern times.
Medicinal Inorganic Chemistry
Molecular chemistry of consequence to renewable energy.
This work has begun to explore poorly understood areas of molecular science with transition-metal complexes that promote hydrogen production and oxygen bond-breaking and -making chemistry of consequence to water splitting.
Boon and Bane of Metal Ions in Medicine
One of the challenges of designing metal-based drugs is to balance the potential toxicity of an active formulation with the substantial positive impact of these increasingly common therapeutic and diagnostic aids.
Structure of ADP·AIF4 –-stabilized nitrogenase complex and its implications for signal transduction
The crystal structure has been determined for the complex between the Fe-protein and MoFe-protein components of nitrogenase stabilized by ADP·AIF4–, previously used as a nucleoside triphosphate analogue in nucleotide-switch proteins.
Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme
The crystal structure of an unmodified hammerhead RNA in the absence of divalent metal ions has been solved, and it was shown that this ribozyme can cleave itself in the crystal when divalent metal
Crystal structure of deoxygenated limulus polyphemus subunit II hemocyanin at 2.18 Å resolution: Clues for a mechanism for allosteric regulation
The rigid body rotation of the first domain suggests a structural mechanism for the allosteric regulation by chloride ions and probably causes the cooperative transition of the hexamer between low and high oxygen affinity states.
Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase.
Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced, azide-bound, and carbon monoxide-bound states were determined at 2.35, 2.9, and 2.8 angstrom resolution, indicating the aspartate as the as partate pumping site for the O2 reduction by the enzyme.