The inner world of overactive monitoring: neural markers of interoception in obsessive–compulsive disorder

@article{Yoris2017TheIW,
  title={The inner world of overactive monitoring: neural markers of interoception in obsessive–compulsive disorder},
  author={Adri{\'a}n Yoris and A M Garc{\'i}a and Liliana Isabel Traiber and Hernando Santamar{\'i}a-Garc{\'i}a and Miguel Martorell and Florencia Alifano and Rafael Kichic and Jason S. Moser and Marcelo Cetkovich and Facundo Manes and Agust{\'i}n Ib{\'a}{\~n}ez and Lucas Sede{\~n}o},
  journal={Psychological Medicine},
  year={2017},
  volume={47},
  pages={1957 - 1970}
}
Background Obsessive–compulsive disorder (OCD) patients typically overmonitor their own behavior, as shown by symptoms of excessive doubt and checking. Although this is well established for the patients’ relationship with external stimuli in the environment, no study has explored their monitoring of internal body signals, a process known to be affected in anxiety-related syndromes. Here, we explored this issue through a cardiac interoception task that measures sensing of heartbeats. Our aim was… 

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References

SHOWING 1-10 OF 105 REFERENCES

Overactive Performance Monitoring as an Endophenotype for Obsessive-Compulsive Disorder: Evidence From a Treatment Study.

This is the first longitudinal study in adult OCD patients showing stability of enhanced error monitoring following successful symptom reduction through CBT, and supports the hypothesis that overactive performance monitoring is an endophenotype that indicates vulnerability for OCD.

Overactive error-related brain activity as a candidate endophenotype for obsessive-compulsive disorder: evidence from unaffected first-degree relatives.

Overactive error monitoring may reflect a trait marker for OCD that is independent of the presence of clinical symptoms, and enhanced error-related brain activity represents a candidate neurocognitive endophenotype for OCD.

Specificity of performance monitoring changes in obsessive-compulsive disorder

Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder.

The findings suggest that different obsessive-compulsive symptom dimensions are mediated by relatively distinct components of frontostriatothalamic circuits implicated in cognitive and emotion processing.

Overactive performance monitoring in obsessive–compulsive disorder is independent of symptom expression

Overactive brain processes during performance monitoring are a neural correlate of OCD that is independent of global symptom severity and can be observed for all symptom dimensions.

An explorative study on metacognition in obsessive-compulsive disorder and panic disorder.

Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

This is the first study in which a multiple lesion model reveals fine-grained alterations of body sensing, offering new theoretical insights into neuroanatomical foundations of interoceptive dimensions.

Cortical Representation of Afferent Bodily Signals in Borderline Personality Disorder: Neural Correlates and Relationship to Emotional Dysregulation.

IMPORTANCE The ability to perceive and regulate one's own emotions has been tightly linked to the processing of afferent bodily signals (interoception). Thus, disturbed interoception might contribute
...