The innate immunity of the central nervous system in chronic pain: The role of Toll-like receptors

@article{Guo2007TheII,
  title={The innate immunity of the central nervous system in chronic pain: The role of Toll-like receptors},
  author={Li Guo and Hermann Josef Schluesener},
  journal={Cellular and Molecular Life Sciences},
  year={2007},
  volume={64},
  pages={1128-1136}
}
Toll-like receptors (TLRs) are a family of pattern recognition receptors that mediate innate immune responses to stimuli from pathogens or endogenous signals. Under various pathological conditions, the central nervous system (CNS) mounts a well-organized innate immune response, in which glial cells, in particular microglia, are activated. Further, the innate immune system has emerged as a promising target for therapeutic control of development and persistence of chronic pain. Especially… CONTINUE READING
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