The injurious effect of eosinophil peroxidase, hydrogen peroxide, and halides on pneumocytes in vitro.

@article{Agosti1987TheIE,
  title={The injurious effect of eosinophil peroxidase, hydrogen peroxide, and halides on pneumocytes in vitro.},
  author={Jan M. Agosti and Leonard C. Altman and Garrison H Ayars and David A. Loegering and Gerald J. Gleich and Seymour J. Klebanoff},
  journal={The Journal of allergy and clinical immunology},
  year={1987},
  volume={79 3},
  pages={496-504}
}
Recent data suggest that eosinophils may cause lung injury. To determine if the eosinophil peroxidase (EPO)-hydrogen peroxide (H2O2)-halide system could mediate this injury, we added human EPO, H2O2 (or glucose and glucose oxidase as a continuous source of H2O2), and various halides to monolayers of 51Cr-labeled human A549 and rat type II pneumocytes. Cell lysis was measured as soluble 51Cr release. In initial experiments, EPO in solution did not induce lysis under these conditions. Therefore… CONTINUE READING
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