The initiation of the limb bud: Growth factors, Hox genes, and retinoids

@article{Tabin1995TheIO,
  title={The initiation of the limb bud: Growth factors, Hox genes, and retinoids},
  author={Clifford J Tabin},
  journal={Cell},
  year={1995},
  volume={80},
  pages={671-674}
}
The undifferentiated vertebrate limb bud is a selforganizing system. If transplanted to a favorable ectopic location, the limb bud is capable of developing into a morphologically normal limb (Harrison, 1918), and the anterior-posterior polarity of the transplanted limb is determined by the graft rather than the host environment. Great progress has recently been made in understanding the molecular steps by which pattern emerges within an undifferentiated limb bud (for recent reviews see Johnson… CONTINUE READING
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