The initiation mess?

  title={The initiation mess?},
  author={John Herrick and Masamichi Kohiyama and Tove Atlung and Flemming Gundorph Hansen},
  journal={Molecular microbiology},
  volume={19 4},
This review concerns the mechanisms which control initiation of chromosome replication in enterobacteria with respect to cell growth. Initiation control is commonly separated into positive and negative regulatory mechanisms. Four main points are advanced concerning these different aspects of initiation control. (i) The average concentration of the initiator protein DnaA is proportional to the origin concentration, i.e. the origin per cell mass ratio and, thus, inversely proportional to the very… CONTINUE READING