The initial noncovalent binding of glucose to human hemoglobin in nonenzymatic glycation.

@article{Clark2013TheIN,
  title={The initial noncovalent binding of glucose to human hemoglobin in nonenzymatic glycation.},
  author={Shelley L D Clark and Angela E Santin and Priscilla A Bryant and Rw Holman and Kenneth J. Rodnick},
  journal={Glycobiology},
  year={2013},
  volume={23 11},
  pages={1250-9}
}
Mechanisms for nonenzymatic protein glycation have been extensively studied albeit with an emphasis at the later stages that gives rise to advanced glycation end products. No detailed investigation of the initial, noncovalent binding of d-glucose to human hemoglobin A (HbA) exists in the literature. Although anionic molecules 2,3-bisphosphoglycerate (BPG), inorganic phosphate (Pi) and HCO3(-) have been implicated in the latter stages of glycation, their involvement at the initial binding of… CONTINUE READING