The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity.

@article{Daly2010TheIR,
  title={The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity.},
  author={D. M. Daly and Russell Chess-Williams and Christopher R Chapple and David Grundy},
  journal={European urology},
  year={2010},
  volume={58 1},
  pages={22-8; discussion 31-2}
}
BACKGROUND The main treatment for overactive bladder (OAB) is the use of anticholinergic drugs initially believed to inhibit the effect of parasympathetic acetylcholine (ACh) on the detrusor; however, there is now evidence to suggest that anticholinergic drugs could interact with sensory pathways. OBJECTIVE Investigate the role of muscarinic receptors and ACh in modulating bladder afferent sensitivity in the mouse. DESIGN, SETTING, AND PARTICIPANTS Bladder and surrounding tissue were… CONTINUE READING
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Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve

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