The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.

@article{Gibson2006TheIP,
  title={The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family.},
  author={Lucien C D Gibson and Stuart F Hastings and Ian McPhee and Robert A Clayton and Claire E Darroch and Alison Mackenzie and Fiona L Mackenzie and Michiaki Nagasawa and Patricia A Stevens and Simon J Mackenzie},
  journal={European journal of pharmacology},
  year={2006},
  volume={538 1-3},
  pages={39-42}
}
Ibudilast is widely used in Japan to treat ischemic stroke and bronchial asthma. Its mode of action is through the inhibition of cyclic nucleotide phosphodiesterases (PDEs). Growing evidence suggests this compound has utility in a range of neurological conditions linked to its ability to elevate cellular cyclic nucleotide concentrations, however limited data exists on Ibudilast's action on individual PDE families. We therefore used an extensive panel of human PDE enzymes to define the PDE… CONTINUE READING
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