The inhibitory mechanism of a novel cationic glucosamine derivative against MMP-2 and MMP-9 expressions.

@article{Mendis2009TheIM,
  title={The inhibitory mechanism of a novel cationic glucosamine derivative against MMP-2 and MMP-9 expressions.},
  author={Eresha Mendis and M K Kim and Niranjan Rajapakse and Se-kwon Kim},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 10},
  pages={
          2755-9
        }
}
A number of recent researches have demonstrated the therapeutic effects of glucosamine (Glc) in a range of human diseases including arthritis. For the first time, we identified that a novel Glc derivative having quaternized amino functionality (QAGlc) suppresses MMP-9 and MMP-2, gelatinases in HT1080, human fibrosarcoma cells at 40microg/ml, following stimulation with PMA. Reporter gene assay results revealed that, the mechanism of suppression involves decreased transcriptional activation of… CONTINUE READING
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